Choosing the right medicine for depression can be hard and confusing, even more so if you are trying to decide between Pristiq and Lexapro. This is because of the following:

• Both Pristiq and Lexapro are common choices for depression.
• They work differently
• Each affects brain chemistry in its way.
• They have different side effects.
• Response depends on individual needs and symptoms.

It is necessary to know such differences to be able to choose the medication that your health needs and your lifestyle are compatible with. This antidepressant comparison article breaks down:

• How each drug works in the brain
• Differences in their effectiveness
• Common and rare side effects
• Withdrawal symptoms and tapering needs
• Who the medication may be better suited for

If it is your first time that you need an antidepressant or you want to change your existing medication, then this guide is just what you need. You can use this article to make a decision that is more confident and informed. Naturally, the input of your healthcare provider will also be necessary.

Overview of Pristiq and Lexapro

Pristiq (desvenlafaxine) is a medicine that belongs to the serotonin-norepinephrine reuptake inhibitor (SNRI) class. That means it acts by increasing the amount of the two primary neurotransmitters in the brain, which are:

• Serotonin; and
• Norepinephrine. 

Benefits of pristiq include:

• Prevents the reabsorption of neurotransmitters.
• Improves communication between brain cells.
• Patients taking this drug might experience an increase in energy.

In contrast, lexapro (escitalopram) is a selective serotonin reuptake inhibitor (SSRI). This medication acts by:

• Just focusing on serotonin reuptake.
• Increasing serotonin for a better mood and less anxiety.

Lexapro is usually a first choice for MDD and GAD, and it has fewer side effects compared to SNRIs.

Even though both drugs are designed to reduce depression symptoms, their mechanisms are different. For example:

These differences highlight the significance of personalized treatment plans.

Pristiq Effectiveness in Treating Depression

When first-line antidepressants like SSRIs fail to deliver results, many patients find relief with Pristiq. Pristiq’s effectiveness was proven in clinical trials to be positive and to help improve overall mental health. 

While not without side effects, its targeted reuptake inhibition makes it a valuable option in the treatment landscape. A brief overview of this drug is represented below:

For treatment-resistant patients with depression, Pristiq can be a good option. This is because this drug works not only on the serotonin pathway but also on the norepinephrine one.

First of all, users themselves say that they have experienced relief in the following symptoms:

• Mood stabilization
• Better focus and clearer thinking
• More energy and less tiredness
• Reduced feeling of despondency or sadness

With that being said, it is also crucial to recognize that the response to Pristiq might not be the same for everyone due to the following factors:

• A person’s body makeup
• Metabolism
• Existing health conditions 
• If they are on other medications 
• Age and gender
• Lifestyle factors such as diet, alcohol use, or smoking
• Stress levels or ongoing life events

These can all affect how patients respond to an antidepressant. 

So, there is no reason to be worried if, after a while, you observe that the drug isn’t working for you. A healthcare professional needs to keep a close eye on the patient during the beginning of the therapy with any antidepressant.

This is to determine:

• How well the medication is working
• If side effects are manageable
• Whether the dose needs adjusting
• If a different treatment might be a better fit

Lexapro Effectiveness in Managing Depression

Lexapro, unlike Pristiq, only deals with and inhibits the reabsorption of serotonin in the brain. 

By allowing serotonin not to be reabsorbed too fast, Lexapro keeps more of this neurotransmitter in the synaptic spaces between the neurons. Serotonin is a major player in: 

• Mood regulation
• Sleep
• Appetite
• Emotional balance 

In general, Lexapro becomes the ace that wins for both MDD and GAD.

The positive effects of Lexapro on depression and anxiety symptoms include:

• Effects appear in 1 to 4 weeks
• Made emotional stability and mental clarity better
• Lower relapse rates in long-term treatment
• Minimal drug interactions, which makes it safer for those who are taking multiple medications

There is no doubt that Lexapro has the capability to alleviate symptoms with relatively mild and short-lived side effects, if any. This makes it the most favored choice by psychiatrists and even primary care providers who are managing cases of mild to moderate depression or anxiety.

Though, in the same breath as all other antidepressants, the reactions of individuals are divergent. 

• Some people get relief from symptoms quite quickly. 
• Other people may require changes in dosage or further help to reach the desired state. 

Still, Lexapro is at the top of the list of the most widely trusted and prescribed antidepressants worldwide.

Understanding Serotonin Reuptake Inhibitors and Their Role

Serotonin reuptake inhibitors consist of substances that fill the brain with serotonin by blocking the process of its reabsorption. 

• An SSRI like Lexapro works only on the serotonin system
• Whereas an SNRI such as Pristiq affects both the serotonin and norepinephrine systems. 

This difference is the way each medication influences 

• Mood
• Anxiety
• Energy 

Thus, the knowledge of the mechanism makes it clear why one medicine can be more effective for a person than the other.

Comparing Pristiq Side Effects and Lexapro Side Effects

Side effects play a significant role in medication choice. Here’s a breakdown of what users commonly experience:

Pristiq Withdrawal Symptoms

If you abruptly stop taking Pristiq, it shouldn’t be a surprise that you might experience severe withdrawal symptoms, which may include:

• Dizziness
• Nausea
• Irritability
• Headaches
• Sensory disturbances

Lexapro Withdrawal Symptoms

While generally milder, Lexapro withdrawal symptoms can still occur. These include:

• Mood swings
• Sleep disturbances
• Flu-like symptoms
• Dizziness

Gradual dose reduction under medical supervision can significantly reduce the severity of these symptoms.

Learn More About Antidepressants at Los Angeles Mental Health

The selection of Pristiq vs Lexapro must not be a decision you make alone. The circumstances of each person’s depression and the effect of antidepressants are unique.

Los Angeles Mental Health is here to help you decide which solution is best for you. We offer you tailored care, professional assistance, and empathize with you throughout your mental health journey.

FAQs

What are the key differences in effectiveness between Pristiq and Lexapro for treating depression?

The days of feeling low because of depression, with little to no energy for daily tasks, are long gone with Pristiq. However, if you want a drug with few symptoms but that is still effective, then choose Lexapro.

How do the side effects of Pristiq compare to those of Lexapro?

Pristiq has its drawbacks and may cause hypertension. Also, if you don’t want to go through the day feeling drowsy, then we are sorry to say, Lexapro might not be for you. But no drug is perfect, and these symptoms are a possibility, not a certainty. 

What role do serotonin reuptake inhibitors play in the effectiveness of Pristiq and Lexapro?

These drugs work by simply ensuring that your brain serotonin levels are high. Sounds easy enough, right? With these drugs, you can focus more on your tasks, and it also improves your mood. 

What are the common withdrawal symptoms associated with Pristiq, and how do they compare to those of Lexapro?

Pristiq can cause irritability, but Lexapro symptoms are anticipated to be milder and expressed in mood change and dizziness.

How do Pristiq and Lexapro differ in managing withdrawal symptoms during the transition period?

Usually, Pristiq means more caution because its withdrawal symptoms are more severe. Lexapro is of a lower power and generally allows users to transition easily to smaller doses.